| Protein Name | flavin containing dimethylaniline monoxygenase 4 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2329 |
| Gene Symbol | FMO4 |
| UniProt | P31512 (FMO4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
4
Total Number of Articles : 4 |
Description |
flavin containing dimethylaniline monoxygenase 4 |
| Gene Summary |
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015] |
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