| Protein Name | Sp1 transcription factor |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6667 |
| Gene Symbol | SP1 |
| UniProt | P08047 (SP1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
151
Total Number of Articles : 158 |
Description |
Sp1 transcription factor |
| Gene Summary |
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
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