Protein Name ERCC excision repair 4, endonuclease catalytic subunit
Organism Homo sapiens
Gene ID 2072
Gene Symbol

ERCC4

UniProt Q92889 (XPF_HUMAN), A0A1W1GSK9 (A0A1W1GSK9_HUMAN), B4DXD8 (B4DXD8_HUMAN)
Relationships Total Number of functionally related compound(s) : 87
Total Number of Articles : 115
Description

ERCC excision repair 4, endonuclease catalytic subunit

Gene Summary

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

synonyms
  • DNA repair endonuclease XPF
  • DNA excision repair protein ERCC-4
  • DNA repair protein complementing XP-F cells
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Properties