| Protein Name | endothelial PAS domain protein 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13819 |
| Gene Symbol | Epas1 |
| UniProt | P97481 (EPAS1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
133
Total Number of Articles : 195 |
Description |
endothelial PAS domain protein 1 |
| Gene Summary |
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in mRNA transcription by RNA polymerase II; myoblast fate commitment; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; norepinephrine metabolic process; and surfactant homeostasis. Located in cytoplasm and nuclear speck. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Jun 2025] |
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