| Protein Name | proteasome 20S subunit beta 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5689 |
| Gene Symbol | PSMB1 |
| UniProt | P20618 (PSB1_HUMAN), A0A140VK45 (A0A140VK45_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
7
Total Number of Articles : 6 |
Description |
proteasome 20S subunit beta 1 |
| Gene Summary |
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008] |
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