| Protein Name | stimulator of interferon response cGAMP interactor 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 72512 |
| Gene Symbol | Sting1 |
| UniProt | Q3TBT3 (STING_MOUSE), A0A2R3XZC4 (A0A2R3XZC4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
62
Total Number of Articles : 58 |
Description |
stimulator of interferon response cGAMP interactor 1 |
| Gene Summary |
Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including macroautophagy; positive regulation of innate immune response; and positive regulation of metabolic process. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including Golgi membrane; autophagosome; and perinuclear region of cytoplasm. Part of STING complex. Is active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in ductus deferens; epididymis; ileum; liver; and prostate gland. Used to study STING-associated vasculopathy with onset in infancy. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Jul 2025] |
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