Protein Name protein disulfide isomerase family A member 2
Organism Homo sapiens
Gene ID 64714
Gene Symbol

PDIA2

UniProt Q13087 (PDIA2_HUMAN)
Relationships Total Number of functionally related compound(s) : 87
Total Number of Articles : 75
Description

protein disulfide isomerase family A member 2

Gene Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]

synonyms
  • protein disulfide-isomerase A2
  • Rho GDP dissociation inhibitor gamma
  • pancreas-specific protein disulfide isomerase
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Properties