Protein Name GLI family zinc finger 3
Organism Homo sapiens
Gene ID 2737
Gene Symbol


UniProt P10071 (GLI3_HUMAN), A0A2R8YGX0 (A0A2R8YGX0_HUMAN)
Relationships Total Number of functionally related compound(s) : 36
Total Number of Articles : 35

GLI family zinc finger 3

Gene Summary

This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

  • transcriptional activator GLI3
  • GLI-Kruppel family member GLI3
  • glioma-associated oncogene family zinc finger 3
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