| Protein Name | origin recognition complex subunit 1 |
|---|---|
| Organism | Saccharomyces cerevisiae S288C |
| Gene ID | 854937 |
| Gene Symbol | ORC1 |
| UniProt | P54784 (ORC1_YEAST) |
| Relationships |
Total Number of functionally related compound(s) :
14
Total Number of Articles : 19 |
Description |
origin recognition complex subunit 1 |
| Gene Summary |
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and DNA replication origin binding activity. Involved in maintenance of rDNA; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and silent mating-type cassette heterochromatin formation. Acts upstream of or within DNA replication initiation and nucleosome organization. Located in nucleus. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Used to study Meier-Gorlin syndrome. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Jun 2025] |
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