| Protein Name | betacellulin, epidermal growth factor family member |
|---|---|
| Organism | Mus musculus |
| Gene ID | 12223 |
| Gene Symbol | Btc |
| UniProt | Q05928 (BTC_MOUSE), Q543J8 (Q543J8_MOUSE), Q3TP84 (Q3TP84_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
21
Total Number of Articles : 24 |
Description |
betacellulin, epidermal growth factor family member |
| Gene Summary |
This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011] |
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| Properties | |