Protein Name cholinergic receptor, nicotinic, alpha polypeptide 4
Organism Mus musculus
Gene ID 11438
Gene Symbol

Chrna4

UniProt O70174 (ACHA4_MOUSE), Q53YK0 (Q53YK0_MOUSE)
Relationships Total Number of functionally related compound(s) : 17
Total Number of Articles : 25
Description

cholinergic receptor, nicotinic, alpha polypeptide 4

Gene Summary

Enables acetylcholine-gated monoatomic cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic signaling. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • neuronal acetylcholine receptor subunit alpha-4
  • a4 nicotinic receptor
  • acetylcholine receptor alpha 4 neural
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Properties