| Protein Name | paired box 6a |
|---|---|
| Organism | Danio rerio |
| Gene ID | 30567 |
| Gene Symbol | pax6a |
| UniProt | P26630 (PAX6_DANRE), A0A0R4IXU2 (A0A0R4IXU2_DANRE) |
| Relationships |
Total Number of functionally related compound(s) :
13
Total Number of Articles : 10 |
Description |
paired box 6a |
| Gene Summary |
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of cell population proliferation; retinal cone cell differentiation; and retinal rod cell differentiation. Acts upstream of or within several processes, including brain development; neural crest cell migration; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including immature eye; nervous system; neural keel; neural plate; and neural rod. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |