| Protein Name | transcriptional and immune response regulator |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 56892 |
| Gene Symbol | TCIM |
| UniProt | Q9NR00 (TCIM_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
33
Total Number of Articles : 34 |
Description |
transcriptional and immune response regulator |
| Gene Summary |
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011] |
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