Protein Name integrin subunit beta 2
Organism Rattus norvegicus
Gene ID 309684
Gene Symbol

Itgb2

UniProt B2RYB8 (B2RYB8_RAT)
Relationships Total Number of functionally related compound(s) : 78
Total Number of Articles : 87
Description

integrin subunit beta 2

Gene Summary

Contributes to cell adhesion molecule binding activity. Involved in several processes, including leukocyte migration involved in inflammatory response; positive regulation of NF-kappaB transcription factor activity; and positive regulation of nitric oxide biosynthetic process. Located in cell surface. Used to study nephritis and pneumonia. Biomarker of allergic rhinitis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • integrin beta-2
  • CD18 leukocyte adhesion molecule
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
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Properties