| Protein Name | bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 |
|---|---|
| Organism | Saccharomyces cerevisiae S288C |
| Gene ID | 856569 |
| Gene Symbol | DNA2 |
| UniProt | P38859 (DNA2_YEAST) |
| Relationships |
Total Number of functionally related compound(s) :
15
Total Number of Articles : 11 |
Description |
bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 |
| Gene Summary |
Enables catalytic activity, acting on DNA and telomeric G-quadruplex DNA binding activity. Involved in DNA metabolic process and G-quadruplex DNA unwinding. Located in chromosome, telomeric region; cytoplasm; and nucleus. Used to study Bloom syndrome and Werner syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |