| Protein Name | SH3 and multiple ankyrin repeat domains 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 243961 |
| Gene Symbol | Shank1 |
| UniProt | D3YZU1 (SHAN1_MOUSE), D3YZU5 (D3YZU5_MOUSE), D3YZU4 (D3YZU4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 11 |
Description |
SH3 and multiple ankyrin repeat domains 1 |
| Gene Summary |
Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and righting reflex. Acts upstream of with a positive effect on AMPA selective glutamate receptor signaling pathway. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in dendritic spine; excitatory synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex; frontal cortex; and neocortex region. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Jul 2025] |
| synonyms |
|
| Properties | |