Protein Name tight junction protein 1
Organism Rattus norvegicus
Gene ID 292994
Gene Symbol

Tjp1

UniProt F1M4A0 (F1M4A0_RAT)
Relationships Total Number of functionally related compound(s) : 240
Total Number of Articles : 256
Description

tight junction protein 1

Gene Summary

Enables beta-catenin binding activity and transmembrane transporter binding activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of vascular permeability; and response to lipopolysaccharide. Located in bicellular tight junction and gap junction. Biomarker of several diseases, including brain ischemia; metabolic dysfunction and alcohol associated liver disease; peptic esophagitis; perinatal necrotizing enterocolitis; and uveitis. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • tight junction protein ZO-1
  • zona occludens 1
  • zona occludens protein 1
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Properties