| Protein Name | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5287 |
| Gene Symbol | PIK3C2B |
| UniProt | O00750 (P3C2B_HUMAN), A2RUF7 (A2RUF7_HUMAN), Q4LE65 (Q4LE65_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
31
Total Number of Articles : 22 |
Description |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta |
| Gene Summary |
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008] |
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