Protein Name MEFV innate immunity regulator, pyrin
Organism Rattus norvegicus
Gene ID 58923
Gene Symbol

Mefv

UniProt Q9JJ25 (MEFV_RAT), A0A0G2JXG0 (A0A0G2JXG0_RAT)
Relationships Total Number of functionally related compound(s) : 5
Total Number of Articles : 3
Description

MEFV innate immunity regulator, pyrin

Gene Summary

Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in response to lipopolysaccharide and response to silicon dioxide. Predicted to be located in nucleus and plasma membrane. Predicted to be part of canonical inflammasome complex and microtubule associated complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to human MEFV (MEFV innate immunity regulator, pyrin). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • pyrin
  • MEFV innate immuity regulator, pyrin
  • MEFV, pyrin innate immunity regulator
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Properties