Protein Name erb-b2 receptor tyrosine kinase 2
Organism Danio rerio
Gene ID 386966
Gene Symbol

erbb2

UniProt Q5EBY4 (Q5EBY4_DANRE)
Relationships Total Number of functionally related compound(s) : 7
Total Number of Articles : 4
Description

erb-b2 receptor tyrosine kinase 2

Gene Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including glial cell development; heart development; and mesenchymal cell differentiation. Predicted to be located in several cellular components, including early endosome; perinuclear region of cytoplasm; and ruffle membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including anterior segment eye; cranial ganglion; fin; heart; and primary neurons. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • receptor tyrosine-protein kinase erbB-2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • wu:fv70f10
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Properties