Protein Name N-glycanase 1
Organism Homo sapiens
Gene ID 55768
Gene Symbol


UniProt Q96IV0 (NGLY1_HUMAN)
Relationships Total Number of functionally related compound(s) : 108
Total Number of Articles : 126

N-glycanase 1

Gene Summary

This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

  • peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
  • hPNGase
  • peptide:N-glycanase
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