| Protein Name | Sp7 transcription factor 7 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 170574 |
| Gene Symbol | Sp7 |
| UniProt | Q8VI67 (SP7_MOUSE), Q5RM08 (Q5RM08_MOUSE), Q2KHK9 (Q2KHK9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
178
Total Number of Articles : 165 |
Description |
Sp7 transcription factor 7 |
| Gene Summary |
Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cementum mineralization; diphosphate metabolic process; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within osteoblast differentiation and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; facial prominence; genitourinary system; jaw; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Jul 2025] |
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