| Protein Name | CCCTC-binding factor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13018 |
| Gene Symbol | Ctcf |
| UniProt | Q61164 (CTCF_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
44
Total Number of Articles : 41 |
Description |
CCCTC-binding factor |
| Gene Summary |
Enables chromatin binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in chromatin looping; negative regulation of gene expression; and positive regulation of gene expression. Acts upstream of or within several processes, including cardiac muscle cell development; epigenetic regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Jul 2025] |
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