Protein Name non-homologous end joining factor
Organism Mus musculus
Gene ID 227622
Gene Symbol

Paxx

UniProt Q8K0Y7 (PAXX_MOUSE)
Relationships Total Number of functionally related compound(s) : 1
Total Number of Articles : 2
Description

non-homologous end joining factor

Gene Summary

Predicted to enable DNA polymerase binding activity; molecular adaptor activity; and protein homodimerization activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in nucleoplasm. Predicted to be part of Ku70:Ku80 complex and nonhomologous end joining complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in brain; cortical plate; lung; spleen; and thymus. Orthologous to human PAXX (PAXX non-homologous end joining factor). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • protein PAXX
  • paralog of XRCC4 and XLF
  • D930050G13Rik
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Properties