| Protein Name | dopamine receptor D2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24318 |
| Gene Symbol | Drd2 |
| UniProt | P61169 (DRD2_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
231
Total Number of Articles : 404 |
Description |
dopamine receptor D2 |
| Gene Summary |
Enables several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of phosphate metabolic process; and regulation of signal transduction. Located in several cellular components, including cytoplasmic vesicle; lateral plasma membrane; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study Parkinsonism; cocaine dependence; fetal alcohol spectrum disorder; and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |