Protein Name DnaJ heat shock protein family (Hsp40) member C24
Organism Homo sapiens
Gene ID 120526
Gene Symbol

DNAJC24

UniProt Q6P3W2 (DJC24_HUMAN)
Relationships Total Number of functionally related compound(s) : 9
Total Number of Articles : 7
Description

DnaJ heat shock protein family (Hsp40) member C24

Gene Summary

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

synonyms
  • dnaJ homolog subfamily C member 24
  • 1700030A21Rik
  • CSL-type zinc finger-containing protein 3
Click to show/hide the synonyms
Properties