| Protein Name | forkhead box J1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15223 |
| Gene Symbol | Foxj1 |
| UniProt | Q61660 (FOXJ1_MOUSE), Q640Q8 (Q640Q8_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 7 |
Description |
forkhead box J1 |
| Gene Summary |
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of lymphocyte activation; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cell maturation; determination of left/right symmetry; and establishment of apical/basal cell polarity. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; nose; and respiratory system. Used to study Kartagener syndrome; congenital heart disease; and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1). [provided by Alliance of Genome Resources, Apr 2025] |
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| Properties | |