| Protein Name | polypeptide N-acetylgalactosaminyltransferase 6 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 11226 |
| Gene Symbol | GALNT6 |
| UniProt | Q8NCL4 (GALT6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
10
Total Number of Articles : 11 |
Description |
polypeptide N-acetylgalactosaminyltransferase 6 |
| Gene Summary |
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008] |
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