Protein Name dermatan sulfate epimerase
Organism Homo sapiens
Gene ID 29940
Gene Symbol


UniProt Q9UL01 (DSE_HUMAN), A0A2R8YE23 (A0A2R8YE23_HUMAN), A0A2U3TZJ0 (A0A2U3TZJ0_HUMAN), B7Z1T3 (B7Z1T3_HUMAN), B7Z765 (B7Z765_HUMAN)
Relationships Total Number of functionally related compound(s) : 20
Total Number of Articles : 19

dermatan sulfate epimerase

Gene Summary

The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]

  • dermatan-sulfate epimerase
  • DS epimerase
  • chondroitin-glucuronate 5-epimerase
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