| Protein Name | secreted frizzled related protein 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6422 |
| Gene Symbol | SFRP1 |
| UniProt | Q8N474 (SFRP1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
139
Total Number of Articles : 147 |
Description |
secreted frizzled related protein 1 |
| Gene Summary |
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] |
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| Properties | |