Protein Name aralkylamine N-acetyltransferase
Organism Gallus gallus
Gene ID 396066
Gene Symbol

AANAT

UniProt P79774 (SNAT_CHICK)
Relationships Total Number of functionally related compound(s) : 68
Total Number of Articles : 84
Description

aralkylamine N-acetyltransferase

Gene Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]

synonyms
  • serotonin N-acetyltransferase
  • AA-NAT
  • arylalkylamine N-acetyltransferase
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Properties