| Protein Name | gamma-aminobutyric acid type B receptor subunit 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 81657 |
| Gene Symbol | Gabbr1 |
| UniProt | Q9Z0U4 (GABR1_RAT), Q6MFX8 (Q6MFX8_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
20
Total Number of Articles : 33 |
Description |
gamma-aminobutyric acid type B receptor subunit 1 |
| Gene Summary |
Enables G protein-coupled GABA receptor activity; extracellular matrix protein binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of adenylate cyclase activity; neuron-glial cell signaling; and regulation of secretion. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in several cellular components, including axolemma; dendrite; and synaptic vesicle. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study alcohol dependence. Biomarker of hypertension. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |