| Protein Name | calpastatin |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25403 |
| Gene Symbol | Cast |
| UniProt | P27321 (ICAL_RAT), A0A0G2JSY2 (A0A0G2JSY2_RAT), F1LPH1 (F1LPH1_RAT), D3ZL24 (D3ZL24_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
18
Total Number of Articles : 15 |
Description |
calpastatin |
| Gene Summary |
Enables calcium-dependent cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ regeneration; myoblast fusion; and skeletal muscle atrophy. Located in membrane and postsynaptic density. Used to study brain ischemia. Biomarker of alcohol use disorder; hypertension; and muscular atrophy. Human ortholog(s) of this gene implicated in PLACK syndrome; Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |