Protein Name mitogen activated protein kinase kinase 2
Organism Rattus norvegicus
Gene ID 58960
Gene Symbol

Map2k2

UniProt P36506 (MP2K2_RAT)
Relationships Total Number of functionally related compound(s) : 13
Total Number of Articles : 16
Description

mitogen activated protein kinase kinase 2

Gene Summary

Enables ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression; peptidyl-tyrosine phosphorylation; and response to ischemia. Located in cell cortex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • dual specificity mitogen-activated protein kinase kinase 2
  • ERK activator kinase 2
  • MAP kinase kinase 2
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Properties