| Protein Name | decapping enzyme, scavenger |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 28960 |
| Gene Symbol | DCPS |
| UniProt | Q96C86 (DCPS_HUMAN), A0A384MTI8 (A0A384MTI8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
73
Total Number of Articles : 44 |
Description |
decapping enzyme, scavenger |
| Gene Summary |
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017] |
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