| Protein Name | Xeroderma pigmentosum D |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 37414 |
| Gene Symbol | Xpd |
| UniProt | Q7KVP9 (Q7KVP9_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
3
Total Number of Articles : 1 |
Description |
Xeroderma pigmentosum D |
| Gene Summary |
Predicted to enable 5'-3' DNA helicase activity and damaged DNA binding activity. Involved in several processes, including regulation of chromosome segregation; regulation of mitotic cell cycle; and response to UV. Located in cytoplasm; nucleus; and polytene chromosome. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in embryonic cortex; embryonic/larval fat body; embryonic/larval salivary gland; and organism. Used to study Cockayne syndrome; photosensitive trichothiodystrophy; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |