Protein Name TNF superfamily member 11
Organism Homo sapiens
Gene ID 8600
Gene Symbol

TNFSF11

UniProt O14788 (TNF11_HUMAN), Q5T9Y4 (Q5T9Y4_HUMAN), Q54A98 (Q54A98_HUMAN)
Relationships Total Number of functionally related compound(s) : 766
Total Number of Articles : 1101
Description

TNF superfamily member 11

Gene Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

synonyms
  • tumor necrosis factor ligand superfamily member 11
  • TNF-related activation-induced cytokine
  • osteoclast differentiation factor
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Properties