| Protein Name | polypeptide N-acetylgalactosaminyltransferase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2589 |
| Gene Symbol | GALNT1 |
| UniProt | Q10472 (GALT1_HUMAN), A0A024RC48 (A0A024RC48_HUMAN), Q05BM8 (Q05BM8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
22
Total Number of Articles : 19 |
Description |
polypeptide N-acetylgalactosaminyltransferase 1 |
| Gene Summary |
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008] |
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