| Protein Name | proteasome 20S subunit alpha 6 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5687 |
| Gene Symbol | PSMA6 |
| UniProt | P60900 (PSA6_HUMAN), A0A140VK44 (A0A140VK44_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 7 |
Description |
proteasome 20S subunit alpha 6 |
| Gene Summary |
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013] |
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| Properties | |