Protein Name Fc receptor, IgG, low affinity III
Organism Mus musculus
Gene ID 14131
Gene Symbol

Fcgr3

UniProt A0A0B4J1M6 (A0A0B4J1M6_MOUSE), E9PUV2 (E9PUV2_MOUSE)
Relationships Total Number of functionally related compound(s) : 62
Total Number of Articles : 59
Description

Fc receptor, IgG, low affinity III

Gene Summary

Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc gamma receptor IIa). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • low affinity immunoglobulin gamma Fc region receptor III
  • Fc gamma receptor III
  • Fcg receptor III
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Properties