| Protein Name | Phosphatase and tensin homolog |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 43991 |
| Gene Symbol | Pten |
| UniProt | Q7KMQ6 (Q7KMQ6_DROME), Q9V3L4 (Q9V3L4_DROME), Q9Y0B6 (Q9Y0B6_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
16
Total Number of Articles : 15 |
Description |
Phosphatase and tensin homolog |
| Gene Summary |
Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein serine/threonine phosphatase activity. Involved in several processes, including negative regulation of hemocyte differentiation; negative regulation of signal transduction; and regulation of neuron projection development. Located in endosome membrane. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; medullary zone of lymph gland primary lobe; and organism. Used to study cancer and disease of metabolism. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |