| Protein Name | centromere protein H |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 64946 |
| Gene Symbol | CENPH |
| UniProt | Q9H3R5 (CENPH_HUMAN), A0A0S2Z5T0 (A0A0S2Z5T0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
11
Total Number of Articles : 12 |
Description |
centromere protein H |
| Gene Summary |
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008] |
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| Properties | |