Protein Name hydroxysteroid (17-beta) dehydrogenase 3
Organism Rattus norvegicus
Gene ID 117182
Gene Symbol

Hsd17b3

UniProt O54939 (DHB3_RAT)
Relationships Total Number of functionally related compound(s) : 114
Total Number of Articles : 121
Description

hydroxysteroid (17-beta) dehydrogenase 3

Gene Summary

Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in several processes, including Leydig cell differentiation; response to fungicide; and response to herbicide. Predicted to be active in endoplasmic reticulum membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • 17-beta-hydroxysteroid dehydrogenase type 3
  • 17-beta-HSD 3
  • 17beta-HSD
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Properties