| Protein Name | transcription factor 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21423 |
| Gene Symbol | Tcf3 |
| UniProt | P15806 (TFE2_MOUSE), A0A0R4J014 (A0A0R4J014_MOUSE), E9PWE2 (E9PWE2_MOUSE), E9PWE4 (E9PWE4_MOUSE), E9PVV1 (E9PVV1_MOUSE), A0A0R4J011 (A0A0R4J011_MOUSE), E9PVV2 (E9PVV2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
30
Total Number of Articles : 22 |
Description |
transcription factor 3 |
| Gene Summary |
Enables several functions, including E-box binding activity; protein heterodimerization activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in gastrulation; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including histone acetylation; immune system development; and regulation of gene expression. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex and nucleosome. Is expressed in several structures, including branchial arch; central nervous system; male reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |