| Protein Name | TIR domain containing adaptor protein |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 680127 |
| Gene Symbol | Tirap |
| UniProt | D3ZXA5 (D3ZXA5_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
4
Total Number of Articles : 2 |
Description |
TIR domain containing adaptor protein |
| Gene Summary |
Predicted to enable several functions, including Toll-like receptor binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including TIRAP-dependent toll-like receptor 4 signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including myeloid cell differentiation; positive regulation of macrophage cytokine production; and response to bacterium. Predicted to be located in endocytic vesicle and ruffle membrane. Predicted to be active in cell surface; cytoplasm; and plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |