| Protein Name | shaggy |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 31248 |
| Gene Symbol | sgg |
| UniProt | P18431 (SGG_DROME), Q7KVY5 (Q7KVY5_DROME), C0PUX5 (C0PUX5_DROME), A4V3W2 (A4V3W2_DROME), M9PGV7 (M9PGV7_DROME), A8JUV9 (A8JUV9_DROME), A4V3W1 (A4V3W1_DROME), H5V852 (H5V852_DROME), B6IDN4 (B6IDN4_DROME), Q0KHW6 (Q0KHW6_DROME), M9PGC4 (M9PGC4_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
26
Total Number of Articles : 35 |
Description |
shaggy |
| Gene Summary |
Enables protein serine/threonine kinase activity. Involved in several processes, including learning; regionalization; and regulation of signal transduction. Located in several cellular components, including female germline ring canal; fusome; and microtubule cytoskeleton. Part of beta-catenin destruction complex. Is expressed in several structures, including brain; epithelium; germ layer; gut section; and synaptic neuropil domain. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to several human genes including GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
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| Properties | |