CPRiL

H2-K1

histocompatibility 2, K1, K region

Enables peptide antigen binding activity. Acts upstream of or within several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; and positive regulation of T cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and retina. Used to study myositis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-F (major histocompatibility complex, class I, F). [provided by Alliance of Genome Resources, Jun 2025]

• H-2 class I histocompatibility antigen, K-W28 alpha chain
• H-2 class I histocompatibility antigen, K-B alpha chain
• H-2 class I histocompatibility antigen, K-D alpha chain
H-2 class I histocompatibility antigen, K-K alpha chain
H-2 class I histocompatibility antigen, K-Q alpha chain
H-2K(B)
H-2K(K)
H-2K(Q)
MHC H2-K transplantation antigen
MHC class I H2-K-b-alpha-2 cell surface glycoprotein
MHC class I antigen
MHC class I heavy chain H2-K
MHC class I heavy chain heavy chain
MHC class I heavy chain maturation peptide
MHC class II antigen D
MHC class II antigen K
class I major histocompatibility antigen H-2Kd
histocompatibility 2, K region, promoter 1
H-2K
H-2K(d)
H2-D1
H2-K
K-f