| Protein Name | sine oculis-related homeobox 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20472 |
| Gene Symbol | Six2 |
| UniProt | Q62232 (SIX2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
7
Total Number of Articles : 7 |
Description |
sine oculis-related homeobox 2 |
| Gene Summary |
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; kidney development; and positive regulation of chondrocyte proliferation. Acts upstream of or within several processes, including chondrocyte differentiation; condensed mesenchymal cell proliferation; and embryonic organ morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study cleft palate. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SIX2 (SIX homeobox 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |