Protein Name platelet derived growth factor subunit B
Organism Homo sapiens
Gene ID 5155
Gene Symbol


UniProt P01127 (PDGFB_HUMAN), A0A384NYY3 (A0A384NYY3_HUMAN)
Relationships Total Number of functionally related compound(s) : 216
Total Number of Articles : 271

platelet derived growth factor subunit B

Gene Summary

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

  • platelet-derived growth factor subunit B
  • PDGF subunit B
  • PDGF, B chain
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