Protein Name cyclin dependent kinase inhibitor 2C
Organism Homo sapiens
Gene ID 1031
Gene Symbol

CDKN2C

UniProt P42773 (CDN2C_HUMAN), Q6ICV4 (Q6ICV4_HUMAN)
Relationships Total Number of functionally related compound(s) : 48
Total Number of Articles : 45
Description

cyclin dependent kinase inhibitor 2C

Gene Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

synonyms
  • cyclin-dependent kinase 4 inhibitor C
  • CDK6 inhibitor p18
  • cyclin-dependent inhibitor
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Properties